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Showing 1 to 12 of 2174 entries
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Patterns of Obesity and Lymph Fluid Level during the First Year of Breast Cancer Treatment: A Prospective Study.

Journal of personalized medicine

Fu MR, Axelrod D, Guth AA, Fletcher J, Qiu JM, Scagliola J, Kleinman R, Ryan CE, Chan N, Haber J.
PMID: 26404383
J Pers Med. 2015 Sep 03;5(3):326-40. doi: 10.3390/jpm5030326.

Obesity is one of the risk factors for developing lymphedema following breast cancer treatment. We prospectively enrolled 140 women and followed the participants for 12 months after surgery to investigate patterns of obesity and lymph fluid level in the...

Prospective Lymphedema Surveillance in a Clinic Setting.

Journal of personalized medicine

Chance-Hetzler J, Armer J, Van Loo M, Anderson B, Harris R, Ewing R, Stewart B.
PMID: 26308061
J Pers Med. 2015 Aug 25;5(3):311-25. doi: 10.3390/jpm5030311.

The potential impact of breast cancer-related lymphedema (LE) is quite extensive, yet it often remains under-diagnosed until the later stages. This project examines the effectiveness of prospective surveillance in post-surgical breast cancer patients. A retrospective analysis of 49 out...

Polymorphisms in FFAR4 (GPR120) Gene Modulate Insulin Levels and Sensitivity after Fish Oil Supplementation.

Journal of personalized medicine

Vallée Marcotte B, Cormier H, Rudkowska I, Lemieux S, Couture P, Vohl MC.
PMID: 29113108
J Pers Med. 2017 Nov 06;7(4). doi: 10.3390/jpm7040015.

The objective was to test whether

The Clinical and Economic Impact of Inaccurate EGFR Mutation Tests in the Treatment of Metastatic Non-Small Cell Lung Cancer.

Journal of personalized medicine

Cheng MM, Palma JF, Scudder S, Poulios N, Liesenfeld O.
PMID: 28657610
J Pers Med. 2017 Jun 28;7(3). doi: 10.3390/jpm7030005.

Advances in personalized medicine are supported by companion diagnostic molecular tests. Testing accuracy is critical for selecting patients for optimal therapy and reducing treatment-related toxicity. We assessed the clinical and economic impact of inaccurate test results between laboratory developed...

Tailoring Nutritional Advice for Mexicans Based on Prevalence Profiles of Diet-Related Adaptive Gene Polymorphisms.

Journal of personalized medicine

Ojeda-Granados C, Panduro A, Gonzalez-Aldaco K, Sepulveda-Villegas M, Rivera-Iñiguez I, Roman S.
PMID: 29125573
J Pers Med. 2017 Nov 10;7(4). doi: 10.3390/jpm7040016.

Diet-related adaptive gene (DRAG) polymorphisms identified in specific populations are associated with chronic disorders in carriers of the adaptive alleles due to changes in dietary and lifestyle patterns in recent times. Mexico's population is comprised of Amerindians (AM) and...

Clinical Pharmacogenetics of Cytochrome P450-Associated Drugs in Children.

Journal of personalized medicine

Aka I, Bernal CJ, Carroll R, Maxwell-Horn A, Oshikoya KA, Van Driest SL.
PMID: 29099060
J Pers Med. 2017 Nov 02;7(4). doi: 10.3390/jpm7040014.

Cytochrome P450 (CYP) enzymes are commonly involved in drug metabolism, and genetic variation in the genes encoding CYPs are associated with variable drug response. While genotype-guided therapy has been clinically implemented in adults, these associations are less well established...

Rapid collection of biospecimens by automated identification of patients eligible for pharmacoepigenetic studies.

Journal of personalized medicine

Sun YV, Davis RL.
PMID: 25562727
J Pers Med. 2013 Sep 26;3(4):263-74. doi: 10.3390/jpm3040263.

Epigenetics plays an important role in regulating gene expression, and can be modified by environmental factors and physiological conditions. Studying epigenetics is a promising approach to potentially improving the diagnosis, prevention and treatment of human diseases, and to providing...

Molecular therapeutic advances in personalized therapy of melanoma and non-small cell lung cancer.

Journal of personalized medicine

Kelleher FC, Solomon B, McArthur GA.
PMID: 25562798
J Pers Med. 2012 Apr 10;2(2):35-49. doi: 10.3390/jpm2020035.

The incorporation of individualized molecular therapeutics into routine clinical practice for both non-small cell lung cancer (NSCLC) and melanoma are amongst the most significant advances of the last decades in medical oncology. In NSCLC activating somatic mutations in exons...

Infectious Disease Management through Point-of-Care Personalized Medicine Molecular Diagnostic Technologies.

Journal of personalized medicine

Bissonnette L, Bergeron MG.
PMID: 25562799
J Pers Med. 2012 May 02;2(2):50-70. doi: 10.3390/jpm2020050.

Infectious disease management essentially consists in identifying the microbial cause(s) of an infection, initiating if necessary antimicrobial therapy against microbes, and controlling host reactions to infection. In clinical microbiology, the turnaround time of the diagnostic cycle (>24 hours) often...

Formative evaluation of clinician experience with integrating family history-based clinical decision support into clinical practice.

Journal of personalized medicine

Doerr M, Edelman E, Gabitzsch E, Eng C, Teng K.
PMID: 25563219
J Pers Med. 2014 Mar 26;4(2):115-36. doi: 10.3390/jpm4020115.

Family health history is a leading predictor of disease risk. Nonetheless, it is underutilized to guide care and, therefore, is ripe for health information technology intervention. To fill the family health history practice gap, Cleveland Clinic has developed a...

Personalized Medicine's Bottleneck: Diagnostic Test Evidence and Reimbursement.

Journal of personalized medicine

Cohen JP, Felix AE.
PMID: 25563222
J Pers Med. 2014 Apr 04;4(2):163-75. doi: 10.3390/jpm4020163.

BACKGROUND: Personalized medicine is gradually emerging as a transformative field. Thus far, seven co-developed drug-diagnostic combinations have been approved and several dozen post-hoc drug-diagnostic combinations (diagnostic approved after the drug). However, barriers remain, particularly with respect to reimbursement. Purpose,...

Differential transcriptome profile of peripheral white cells to identify biomarkers involved in oxaliplatin induced neuropathy.

Journal of personalized medicine

Morales M, Ávila J, González-Fernández R, Boronat L, Soriano ML, Martín-Vasallo P.
PMID: 25563226
J Pers Med. 2014 Jun 05;4(2):282-96. doi: 10.3390/jpm4020282.

Anticancer chemotherapy (CT) produces non-desirable effects on normal healthy cells and tissues. Oxaliplatin is widely used in the treatment of colorectal cancer and responsible for the development of sensory neuropathy in varying degrees, from complete tolerance to chronic neuropathic...

Showing 1 to 12 of 2174 entries